Escape of Mutant Double-Stranded DNA Virus from Innate Immune Control
نویسندگان
چکیده
منابع مشابه
Double-stranded RNA-activated protein kinase regulates early innate immune responses during respiratory syncytial virus infection.
Respiratory syncytial virus (RSV) is the most common cause of childhood viral bronchiolitis and lung injury. Inflammatory responses significantly contribute to lung pathologies during RSV infections and bronchiolitis but the exact mechanisms have not been completely defined. The double-stranded RNA-activated protein kinase (PKR) functions to inhibit viral replication and participates in several...
متن کاملLigation of double-stranded and single-stranded [oligo(dT)] DNA by vaccinia virus DNA ligase.
Vaccinia virus DNA ligase has been expressed in Escherichia coli, purified, and biochemically characterized. The enzyme ligates double-stranded (ds) DNA substrates with either cohesive or blunt-end termini and the latter reaction is stimulated by PEG. Vaccinia virus DNA ligase can also ligate oligo(dT) when annealed to either a poly(dA) or a poly(rA) backbone and, remarkably, free oligo(dT). Th...
متن کاملPhospholipase D facilitates efficient entry of influenza virus, allowing escape from innate immune inhibition.
Lipid metabolism plays a fundamental role during influenza virus replication, although key regulators of lipid-dependent trafficking and virus production remain inadequately defined. This report demonstrates that infection by influenza virus stimulates phospholipase D (PLD) activity and that PLD co-localizes with influenza during infection. Both chemical inhibition and RNA interference of PLD d...
متن کاملThe double-stranded DNA of cauliflower mosaic virus.
Examination of the physical structure of cauliflower mosaic virus DNA by electron microscopy and ultracentrifugal analysis showed that the DNA could be isolated mainly as a circular molecule of mol. wt. 4"7 x Io 6. Nearest-neighbour frequency analysis showed that the DNA has a chemical structure which exhibits close similarities to that of the host cauliflower DNA. The relationships of this pla...
متن کاملMechanism of capsid maturation in a double-stranded DNA virus.
Folding mechanisms of proteins incorporated within supramolecular assemblies, including viruses, are little understood and may differ fundamentally from folding mechanisms of small globular proteins. We describe a novel Raman dynamic probe of hydrogen-isotope exchange to investigate directly these protein folding/assembly pathways. The method is applied to subunit folding in assembly intermedia...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Immunity
سال: 2004
ISSN: 1074-7613
DOI: 10.1016/j.immuni.2004.05.006